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KMID : 0613820070170060766
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Journal of Life Science
2007 Volume.17 No. 6 p.766 ~ p.771
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Cooperative stimulation of cisplatin-mediated apoptosis by hepatitis B virus X protein and hepatitis C virus core protein
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Kwun Hyun-Jin
Jang Kyung-Lib
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Abstract
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The co-infection with hepatitis B virus (HBV) and hepatitis C Virus (HCV) is associated with a more severe liver disease and increased frequency in the development of hepatocellular carcinoma compared to those with single infection. Here, we demonstrated that HBV X protein (HBx) and HCV Core cooperatively up-regulated the level of p53 in human hepatoma HepG2 cells. The elevated p53 subsequently stimulated the expression of proapoptotic Bax whereas it repressed the expression of anti-apoptotic Bcl2. These effects, however, were not observed in p53-negative Hep3B cells. Consistently to their cooperative regulation of apoptotic effectors, HBx and HCV Core additively stimulated cisplatin-mediated apoptotic cell death of HepG2 but not of Hep3B cells. These results may help to explain the development of a more severe liver disease in patients co-infected with HBV and HCV as well as some contradictory results on the roles of HBx and Core in apoptosis.
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KEYWORD
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Apoptosis, Cisplatin, Core, HBV, HBx, HCV
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